One of the issues that's complicated all-out integration of Zope/Plone and GIS is the lack of spatial indexes for catalogs. Without an index, your data is bottled up in the ZODB. "Find all features within [bbox]" is O(N), and unfeasible for large sets of features. Pleiades needs to overcome this issue soon, and so I've done something about it.
After researching trees of all kinds and reviewing a number of libraries, I finally went with what had been right under my nose all along: the quadtree from the venerable and inscrutable shapelib. A few years ago I would have used SWIG to wrap shapelib's tree, but I honestly don't give a damn about anything but Python these days. I whipped up tests, a Python C extension module, and Quadtree was born.
How does it work? Check out the doctests:
Make an instance >>> from quadtree import Quadtree >>> index = Quadtree([-180, -90, 180, 90]) Add 3 items >>> index.add(0, [-106, 39, -105, 40]) >>> index.add(1, (-100, 25, -95, 30)) >>> index.add(2, (40, 50, 45, 55)) Find likely items >>> [n for n in index.likely_intersection([-110, 30, -100, 45])] [0, 1] >>> [n for n in index.likely_intersection([10, 40, 40.05, 60])]  We get a hit for the next bounding box even though it doesn't explicitly intersect with the item -- it does intersect with the tree node containing the item. >>> [n for n in index.likely_intersection([-110, 35, -108, 45])] 
How well does it work? I've yet to script runs over the entire parameter space (data density, tree extent, query box size, maximum tree depth), but have preliminary results from tests/benchmarks.py. 1000 points are randomly sprinkled in a box bounded by [0, 0, 1, 1]. The "brute force" method of determining whether a point is inside a box is:
p.x >= minx and p.x <= maxx and p.y >= miny and p.y <= maxy
A typical result, averaged over 100 passes:
1000 points Index extent: [-180, -90, 180, 90] Query box: [0.2, 0.3, 0.3, 0.4] Brute Force: 15 hits 1539.89 usec/pass Likely Intersection: 23 hits 42.03 usec/pass Likely Intersection with false positive mop-up: 15 hits 115.35 usec/pass
Making one extra swipe over the likely points in order to mop up the 8 false positives is costly, but is still much faster than comparing each point to the query box. I knew it would be, but it's always encouraging to see the numbers.
Speaking of the way I used to do things ... as recently as May I would have rolled this into the Python Cartographic Library, but have seen the light since then. There's been more interest in OWSLib since I dredged it up from PCL. I'm also inspired by geopy, the single-minded library for accessing geocoding services. Quadtree will be similarly single-minded. It depends on nothing except setuptools (for now). After a little more testing, I'll upload to Cheese Shop.
If it looks useful to you, grab via Subversion:
svn co http://icon.stoa.org/svn/pleiades/Quadtree/trunk Quadtree
and take it for a ride.
P.S. -- five quatloos for the first person to find the Neal Stephenson reference in this post.